Endocrine Abstracts

The study investigated the potential alteration in the level of insulin and adiponectin, as well as the expression of INSR and GLUT-4 in chronic restraint stress rats. Sprague–Dawley rats were randomly divided into two groups: the control group and stress group in which the rats were exposed to one of the four different restraint stressors; 1 h, twice daily for a period of 7 days (S7D), 14 days (S14D) and 28 days (S28D). To minimize habituation, the sequence of the stress...

Virtually all biochemical processes in the body require dietary micro-nutrients and imbalance in any of these essential of the diet have the potential to impair metabolic activities. Deficiencies of several mineral nutrients result in stunting, down-regulated immune responsiveness and altered metabolic activities. Appropriate dietary intake of these mineral nutrients can address this deficiency and is currently recommended as part of a lifestyle intervention for the prevention...

Stress defined as a disruption in the normal homeostatic functions of an organism caused by a stressor (a physiological or psychological challenge) is an unavoidable experience of life. Previous studies suggest that stress hormones have acute adverse effects on glycaemic control. The aim of this study was to assess the effect of chronic psychological and physical stress on the expression of insulin receptor (INSR) and glucose transporter-4 (GLUT4) in male Sprague–Dawley r...

Several epidemiological evidences indicate that consumption of coffee is associated with a lower risk of type 2 diabetes mellitus (T2DM); however, there is dearth of experimental data to support these observations. Given that associations do not necessarily infer causality; the present study investigate the effect of coffee consumption on glucose regulation, T2DM and the probable mechanisms of action, if any, using an animal model. Twenty-four (24) Sprague–Dawley rats wei...

Genistein is an endocrine-disrupting chemical (EDC), derived from soya, with reported adverse effects on fetal development. The placenta regulates fetal environment for fidelity of organogenesis which can be compromised by several external factors including EDCs. This study examined the influence of genistein on the histomorphometry of the Giant Trophoblast Cells (GTC) of the placenta and the oxidative stress balance across the maternal serum, placenta and t...

Genistein is an endocrine-disrupting chemical (EDC), derived from soya, with reported adverse effects on fetal development. The placenta regulates fetal environment for fidelity of organogenesis which can be compromised by several external factors including EDCs. This study examined the influence of genistein on the histomorphometry of the Giant Trophoblast Cells (GTC) of the placenta and the oxidative stress balance across the maternal serum, placenta and t...